de Viragh P A, Meuli M
Department of Dermatology, University Hospital of Lausanne, Switzerland.
Arch Dermatol Res. 1995;287(3-4):279-84. doi: 10.1007/BF01105079.
The depths of hair follicle compartments, and in particular of the bulge, the putative site of hair follicle stem cells, have not yet been determined in human scalp skin from infants, children or adolescents. This information is necessary in order to use the scalp safely as a donor site for skin grafts. We therefore investigated the development of the infundibulum, the bulge, Adamson's fringe, the B-fringe and the matrix by measuring the depths of these five follicular compartments in parietal scalp biopsy specimens from 100 patients ranging in age from 2 weeks to 21 years. The thickness of the epidermis and the dermis were also assessed. The correlations of these measurements with age were determined by regression analysis. The regression equation for the bulge was found to be b (microns) = 683.3 + 30.8y (r = 0.73; SEM = 145.5) where y is the age in years, and for the matrix it was m (microns) = 1616.2 + 90.4y (r = 0.76; SEM = 406.5); P < 0.0001 for the null hypothesis. The growth of the inferior portion below the bulge was not parallel but proportional to that of the superior portion. The relative position of the bulge in the dermis was stable, whereas the inferior portion moved progressively more deeply into the subcutis. These findings provide evidence for the postulated biologically advantageous localization of the bulge, and thus is a further argument in favour of the bulge as the site of follicular stem cells.
在婴儿、儿童或青少年的人类头皮皮肤中，毛囊各部分的深度，尤其是毛囊干细胞假定所在部位——隆突的深度，尚未确定。为了安全地将头皮用作皮肤移植的供体部位，这一信息是必要的。因此，我们通过测量100例年龄在2周龄至21岁之间的患者顶叶头皮活检标本中这五个毛囊部分的深度，研究了漏斗部、隆突、亚当森边缘、B边缘和毛基质的发育情况。还评估了表皮和真皮的厚度。通过回归分析确定这些测量值与年龄的相关性。发现隆突的回归方程为b（微米）= 683.3 + 30.8y（r = 0.73；标准误 = 145.5），其中y为年龄（岁），毛基质的回归方程为m（微米）= 1616.2 + 90.4y（r = 0.76；标准误 = 406.5）；零假设的P < 0.0001。隆突下方下部的生长与上部不平行，但与之成比例。隆突在真皮中的相对位置是稳定的，而下部则逐渐更深地移入皮下组织。这些发现为隆突假定的生物学优势定位提供了证据，因此进一步支持隆突作为毛囊干细胞的所在部位。
