Summerbell D
J Embryol Exp Morphol. 1979 Apr;50:217-33.
When an impermeable barrier is placed so as to divide the early chick limb-bud into anterior and posterior parts then development continues only on one side of the barrier. The detailed results are inconsistent with mosaic development. They can readily be explained by supposing that pattern is specified by the concentration of a diffusible morphogen controlled by the zone of polarizing activity. A simulation of appropriate concentration profiles is presented and its relevance to similar experiments published elswhere is discussed. It seems probable that the zone of polarizing activity is active during normal development.
当放置一个不可渗透的屏障将早期鸡胚肢体芽分成前后两部分时，发育仅在屏障的一侧继续。详细结果与镶嵌发育不一致。通过假设模式由极化活性区域控制的可扩散形态发生素的浓度来指定，这些结果很容易得到解释。给出了适当浓度分布的模拟，并讨论了其与其他地方发表的类似实验的相关性。极化活性区域在正常发育过程中似乎是活跃的。
