Raheem K A, Gründig E, Salvenmoser F, Schedl R, Weiss J
J Clin Chem Clin Biochem. 1979 Jun;17(6):341-8. doi: 10.1515/cclm.1979.17.6.341.
Parkinsonism was induced in rats by using phenothiazines (Butyrylperazin and Thioproperazin). (P-group), or reserpine, (R-group). [U-14 C)D-glucose was administered when the symptoms of Parkinsonism had become fully developed. Concentrations and radioactivities of different metabolites were studied in brain, liver and blood serum. 1. Both types of treatments resulted in a decrease in the synthesis of amino acids from [14C]glucose in the brain. The concentrations of amino acids and the glycogen remained uneffected. Phenothiazines enhanced the conversion of lipids, while reserpine increased their concentration. 2. Reduced de novo synthesis of amino acids was recorded in the liver. Phenothiazines resulted in the storage of glycogen and lipids; reserpine resulted in the storage of lipids and enhanced the conversion of glycogen. 3. Both treatments caused a fall in the amino acid concentration of the blood serum. A rise in the specific radioactivity of blood amino acids was observed in the P-group, while a decrease in specific radioactivity was observed in the R-group. A hyperglycemia was induced in the R-group with reduced specific radioactivity of glucose in both P-and R-groups. A reduction in lipid concentration of blood serum was achieved with an increased specific radioactivity in P-group and decreased radioactivity in R-group. 4. The changes in amino acids common to both treatments are also observed in human Parkinsonism.
使用吩噻嗪类药物（丁酰拉嗪和硫丙嗪）（P组）或利血平（R组）诱导大鼠患帕金森症。当帕金森症症状完全出现后，给予[U-14C]D-葡萄糖。研究了脑、肝和血清中不同代谢物的浓度和放射性。1. 两种治疗方式均导致脑中由[14C]葡萄糖合成氨基酸的量减少。氨基酸浓度和糖原含量未受影响。吩噻嗪类药物增强了脂质的转化，而利血平增加了脂质的浓度。2. 肝脏中从头合成氨基酸的量减少。吩噻嗪类药物导致糖原和脂质的储存；利血平导致脂质的储存并增强了糖原的转化。3. 两种治疗均导致血清中氨基酸浓度下降。在P组中观察到血液氨基酸的比放射性升高，而在R组中观察到比放射性降低。R组诱导出现高血糖，P组和R组中葡萄糖的比放射性均降低。P组血清脂质浓度降低，比放射性增加，R组放射性降低。4. 在人类帕金森症中也观察到了两种治疗共有的氨基酸变化。
