Contreras R J, Frank M
J Gen Physiol. 1979 May;73(5):569-94. doi: 10.1085/jgp.73.5.569.
The effects of sodium deprivation for 10 d, a period sufficient to induce sodium appetite, on gustatory nerve discharges in rats were determined. Chorda tympani responses to concentration series of sodium chloride, sucrose, hydrochloric acid, and quinine hydrochloride were recorded and analyzed without the experimenter knowing the animal's deprivation condition. After deprivation, both whole nerve and single nerve fiber responses to sodium chloride were smaller; NaCl-best fibers, those more responsive to sodium chloride than to sucrose, hydrochloric acid, or quinine, were most affected. Thresholds had not changed; however, slopes of the stimulus-response functions for sodium chloride were lowered. Comparable changes in responses to the other stimuli did not occur. These results were discussed with respect to a possible relationship between changes in sodium chloride responsivity and changes in sodium intake, differences between methods of inducing sodium appetite, coding of taste quality and intensity, and mechanisms which might effect the responsivity change.
确定了剥夺大鼠钠10天（这一时期足以诱发钠食欲）对其味觉神经放电的影响。在实验者不知道动物剥夺情况的条件下，记录并分析了鼓索神经对一系列氯化钠、蔗糖、盐酸和盐酸奎宁浓度的反应。剥夺后，整个神经和单根神经纤维对氯化钠的反应均变小；对氯化钠反应最佳的纤维（即对氯化钠的反应比对蔗糖、盐酸或奎宁更敏感的纤维）受影响最大。阈值没有变化；然而，氯化钠刺激 - 反应函数的斜率降低了。对其他刺激的反应没有出现类似变化。针对氯化钠反应性变化与钠摄入量变化之间可能的关系、诱发钠食欲方法的差异、味觉质量和强度的编码以及可能影响反应性变化的机制，对这些结果进行了讨论。
