正常血压大鼠和自发性高血压大鼠延髓中苯乙醇胺N-甲基转移酶和肾上腺素的分布

Distribution of PNMT and epinephrine in the medulla oblongata of normotensive and spontaneous hypertensive rats.

作者信息

Lew J Y, Hata F, Sauter A, Baba Y, Engel J, Goldstein M

出版信息

J Neural Transm. 1979;44(4):309-16. doi: 10.1007/BF01250326.

Abstract

The distribution of the Epinephrine forming enzyme (PNMT) activity and Epinephrine (E) levels was investigated in the medulla oblongata of spontaneous hypertensive rats (SH-rats) and in two normotensive strains, namely Wistar Kyoto rats (WK-rats) and Wistar rats. The PNMT activity increases progressively from the caudal to rostral parts in the C1 and C2 regions of the medulla oblongata. The enzyme activity and the E levels are in all parts of the C1 and C2 regions higher in Wistar rats than in WK-rats. The PNMT activity in all parts of the C2 region (with the exception of the caudal region), and in the middle part of the C1 region is higher in SH-rats than in WK-rats. The E levels in the SH-rats are higher than in WK-rats in the mediocaudal parts of the C2 and C1 regions.

摘要

研究了自发性高血压大鼠（SH大鼠）以及两种正常血压品系，即Wistar Kyoto大鼠（WK大鼠）和Wistar大鼠延髓中肾上腺素形成酶（PNMT）活性和肾上腺素（E）水平的分布。在延髓的C1和C2区域，PNMT活性从尾部到头部逐渐增加。Wistar大鼠C1和C2区域所有部位的酶活性和E水平均高于WK大鼠。SH大鼠C2区域所有部位（尾部区域除外）以及C1区域中部的PNMT活性高于WK大鼠。SH大鼠C2和C1区域中尾部的E水平高于WK大鼠。