McNamara P J, Colburn W A, Gibaldi M
J Pharmacokinet Biopharm. 1979 Feb;7(1):63-8. doi: 10.1007/BF01059441.
Carbamazepine concentrations in plasma during repetitive oral dosing were analyzed by means of a nonlinear, variable parameter, regression program (VARPARM) assuming dose-to-dose changes in the apparent elimination rate constant of the drug. There was evidence of significant self-induction of carbamazepine metabolism as early as 1 or 2 days after initiation of the multiple-dose study. Additional self-induction appears to occur after about 2 weeks of treatment. The time course of carbamazepine self-induction appears to be complex, discontinuous, and prolonged.
采用非线性可变参数回归程序（VARPARM）分析重复口服给药期间血浆中的卡马西平浓度，该程序假定药物的表观消除速率常数会随剂量变化。早在多剂量研究开始后的1或2天，就有证据表明卡马西平代谢存在显著的自身诱导现象。在治疗约2周后似乎会出现额外的自身诱导。卡马西平自身诱导的时间进程似乎很复杂、不连续且持续时间长。
