睾酮庚酸酯3-二苯乙醇酸腙中的顺反异构化。
syn-anti Isomerization in testosterone 17-enanthate 3-benzilic acid hydrazone.
作者信息
Roman R, Yates C H, Millar J F
出版信息
J Pharm Sci. 1979 Jun;68(6):736-9. doi: 10.1002/jps.2600680622.
PMID:458576
Abstract
UV spectrophotometry, high-pressure liquid chromatography, and NMR were used to investigate syn-anti isomerization in testosterone 17-enanthate 3-benzilic acid hydrazone. In the crystalline state, the isomeric ratio is dependent on the crystallization solvent. In solutions, including injectable pharmaceutical formulations, an equilibrium isomer mixture (2:1) is formed.
摘要
采用紫外分光光度法、高压液相色谱法和核磁共振法研究庚酸睾酮苯甲酰腙的顺反异构化。在结晶状态下，异构体比例取决于结晶溶剂。在溶液中，包括注射用药物制剂中，会形成平衡异构体混合物（2:1）。
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