FK-520主要平衡产物的分离与表征
Isolation and characterization of the major equilibrium product of FK-520.
作者信息
Gailliot F P, Natishan T K, Ballard J M, Reamer R A, Kuczynski D, Mcmanemin G J, Egan R S, Buckland B C
机构信息
Merck Research Laboratories, Rahway, NJ 07065-0900.
出版信息
J Antibiot (Tokyo). 1994 Jul;47(7):806-11. doi: 10.7164/antibiotics.47.806.
PMID:7520900
Abstract
The existence of an isomeric form in equilibrium with the major component of FK-520 in polar solutions has been demonstrated. This minor component has been isolated in high yield and purity by a novel crystallization strategy and preparative HPLC. The equilibrium product was characterized by NMR and MS.
摘要
已证实在极性溶液中，FK - 520的主要成分存在一种与之处于平衡状态的异构体形式。通过一种新颖的结晶策略和制备型高效液相色谱法，已高收率、高纯度地分离出了这种次要成分。通过核磁共振（NMR）和质谱（MS）对平衡产物进行了表征。
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