Luber J R, Visalli A J, Patel D M
J Pharm Sci. 1979 Jun;68(6):780-2. doi: 10.1002/jps.2600680630.
Modified USP procedures are described for the simultaneous determination of nonaspirin salicylates and aspirin in aspirin and buffered aspirin tablets. The existing USP procedures are not stability indicating for intact aspirin when significant levels of nonaspirin salicylates are present, as is often the case in short-term, high temperature stability programs. The modified procedures yeld considerably shorter analysis times and stability-indicating assays for intact aspirin without the need for sophisticated equipment other than that presently required by USP XIX.
描述了修改后的美国药典方法，用于同时测定阿司匹林片和缓冲阿司匹林片中的非阿司匹林水杨酸盐和阿司匹林。当存在大量非阿司匹林水杨酸盐时，现有的美国药典方法对于完整的阿司匹林并不具有稳定性指示作用，短期高温稳定性试验中经常出现这种情况。修改后的方法可显著缩短分析时间，并能对完整的阿司匹林进行稳定性指示测定，除了美国药典第十九版目前要求的设备外，无需其他复杂设备。
