Galante R N, Egoville J C, Visalli A J, Patel D M
J Pharm Sci. 1981 Feb;70(2):167-9. doi: 10.1002/jps.2600700213.
The analysis of aspirin and nonaspirin salicylates in buffered and plain tablet formulations employing nearly nonaqueous extraction is described. The results obtained compare favorably with those obtained from USP procedures. A simultaneous assay for aspirin and nonaspirin salicylates in buffered tablets involves the use of an acidified chromatographic siliceous earth column for the separation of the aspirin and nonaspirin salicylates from various buffers or antacids. The methods described here have definite advantages over USP XX procedures, and the buffered aspirin tablet procedures also is adaptable to aspirin formulations containing codeine, acetaminophen, propoxyphene, caffeine, and many antihistamines.
本文描述了采用近非水萃取法对缓冲片和普通片剂剂型中的阿司匹林及非阿司匹林水杨酸盐进行分析。所得结果与美国药典方法所得结果相比具有优势。对缓冲片中阿司匹林和非阿司匹林水杨酸盐进行同时测定时，需使用酸化的色谱硅胶柱从各种缓冲剂或抗酸剂中分离出阿司匹林和非阿司匹林水杨酸盐。本文所述方法相对于美国药典XX版方法具有明确优势，且缓冲阿司匹林片的测定方法也适用于含有可待因、对乙酰氨基酚、丙氧芬、咖啡因和多种抗组胺药的阿司匹林制剂。
