Iyer B V, Vasavada R C
J Pharm Sci. 1979 Jun;68(6):782-7. doi: 10.1002/jps.2600680631.
The film-forming potential of lanolin alcohol was evaluated. Inclusion of ethylcellulose in lanolin alcohol improved film integrity. The hardness and modulus of elasticity of these lanolin alcohol-ethylcellulose films were improved by incorporating propylene glycol or cetyl alcohol. Triamcinolone acetonide release from selected film compositions was investigated. The data were analyzed from the viewpoint of the first-order kinetic theory and the release from a planar system having a homogeneous or granular matrix. The results suggest that the drug release follows a diffusion-controlled matrix model and a square root of time release profile. The release rate constants were proportional to drug concentration. Drug release was maximal from a system containing the drug in a near-saturated solution.
对羊毛脂醇的成膜潜力进行了评估。在羊毛脂醇中加入乙基纤维素可改善膜的完整性。通过加入丙二醇或十六醇，这些羊毛脂醇-乙基纤维素膜的硬度和弹性模量得到了提高。研究了醋酸曲安奈德从选定膜组合物中的释放情况。从一级动力学理论以及从具有均匀或颗粒状基质的平面系统释放的角度对数据进行了分析。结果表明，药物释放遵循扩散控制的基质模型和时间平方根释放曲线。释放速率常数与药物浓度成正比。在含有接近饱和溶液中药物的系统中，药物释放最大。
