慢性肝病：澳大利亚人和亚洲人自身免疫血清学反应的差异
Chronic liver disease: differences in autoimmune serological reactions between Australians and Asians.
作者信息
Whittingham S, Mackay I R, Thanabalasundrum R S, Chuttani H K, Manjuran R, Seah C S, Yu M, Viranuvatti V
出版信息
Br Med J. 1973 Dec 1;4(5891):517-9. doi: 10.1136/bmj.4.5891.517.
A total of 164 patients from Australia, Ceylon, India, Singapore, and Thailand were studied for the prevalence of autoantibodies associated with "idiopathic" chronic liver disease-namely, antinuclear antibody, smooth muscle antibody, and mitochondrial antibody. The prevalence of these autoantibodies was high among patients from Australia (55%), but was low among patients from Ceylon (14%), India (11%), Singapore (0%), and Thailand (8%). There are variations in types of hepatitis and cirrhosis between races, and this applies particularly to the type associated with autoimmune markers. This may be related to genetic differences that have evolved between peoples of European and Asian descent.
对来自澳大利亚、锡兰、印度、新加坡和泰国的164名患者进行了研究，以了解与“特发性”慢性肝病相关的自身抗体——即抗核抗体、平滑肌抗体和线粒体抗体的流行情况。这些自身抗体在澳大利亚患者中流行率较高（55%），但在锡兰患者中较低（14%），在印度患者中为11%，在新加坡患者中为0%，在泰国患者中为8%。不同种族之间的肝炎和肝硬化类型存在差异，这尤其适用于与自身免疫标志物相关的类型。这可能与欧洲和亚洲血统人群之间进化出的基因差异有关。
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