慢性肝炎中的澳大利亚抗原和自身抗体
Australia antigen and autoantibodies in chronic hepatitis.
作者信息
Vischer T L
出版信息
Br Med J. 1970 Jun 20;2(5711):695-8. doi: 10.1136/bmj.2.5711.695.
The sera of 110 patients with chronic hepatitis and adequate controls were examined for antibodies to smooth muscle (S.M.), mitochondria (M.), and for antinuclear factors by the immunofluorescence method, and for Australia (Au(1)) antigen by a modified micro-Ouchterlony immunodiffusion technique. Twelve out of 13 patients with primary biliary cirrhosis had M. antibodies, two had antinuclear factor, and none had Au(1) in their sera. In chronic aggressive hepatitis 23.5% of the sera contained antinuclear factor, 13% S.M. antibodies, 10.5% M. antibodies, and 22% Au(1) antigen. Of the 12 patients with chronic persistent hepatitis, one had antinuclear factor, one S.M. antibodies, and three Au(1) antigen.The most striking finding was a mutual exclusion between Au(1) antigen and M. and S.M. antibodies. None of the 33 patients with one or the other form of chronic hepatitis and M. or S.M. antibodies had Au(1) antigen; 22 out of 77 (28%) patients without such antibodies were positive.
采用免疫荧光法检测了110例慢性肝炎患者及适当对照的血清中的平滑肌（S.M.）抗体、线粒体（M.）抗体及抗核因子，并采用改良的微量双向免疫扩散技术检测了澳大利亚（Au(1)）抗原。13例原发性胆汁性肝硬化患者中，12例血清中有M.抗体，2例有抗核因子，无一例血清中有Au(1)。在慢性活动性肝炎中，23.5%的血清含有抗核因子，13%有S.M.抗体，10.5%有M.抗体，22%有Au(1)抗原。12例慢性持续性肝炎患者中，1例有抗核因子，1例有S.M.抗体，3例有Au(1)抗原。最显著的发现是Au(1)抗原与M.抗体和S.M.抗体相互排斥。33例患有某种形式慢性肝炎且有M.或S.M.抗体的患者中，无一例有Au(1)抗原；77例无此类抗体的患者中有22例（28%）呈阳性。
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