Umagat H, McGarry P F, Tscherne R J
J Pharm Sci. 1979 Jul;68(7):922-4. doi: 10.1002/jps.2600680741.
Sensitive and efficient methods for sulfonamide determination as single entities and in combination with other drug substances in pharmaceutical dosage formulations were developed using high-performance liquid chromatography. These stability-indicating procedures involved a nitrile bonded phase column and nonaqueous mobile phases having diverse polarities. Sample potency was determined using peak height measurements. The methods may be used to determine trace sulfonamide quantities because detection limits are in the nanogram range.
采用高效液相色谱法开发了用于测定药物剂型中单一磺胺类药物以及与其他药物物质组合的磺胺类药物的灵敏且高效的方法。这些稳定性指示程序涉及腈基键合相柱和具有不同极性的非水流动相。使用峰高测量来确定样品效价。由于检测限在纳克范围内，这些方法可用于测定痕量磺胺类药物的量。
