Elrod L, Cox R D, Plasz A C
J Pharm Sci. 1982 Feb;71(2):161-6. doi: 10.1002/jps.2600710206.
The sulfonamides and erythromycin ethylsuccinate in combination oral suspensions were determined by high-performance liquid chromatography and automated turbidimetry, respectively. The chromatographic procedure was rapid, specific, and stability-indicating for sulfisoxazole acetyl and the trisulfapyrimidines using a reversed-phase system with UV detection at 254 nm. Erythromycin ethylsuccinate did not interfere with the sulfonamide analysis and these compounds were assayed with relative standard deviations (RDS) ranging from +/- 2.1 to +/- 3.1%. Erythromycin ethylsuccinate was determined as erythromycin with RSD values of +/- 1.3 or 3.5% without interference by the sulfonamides present.
分别采用高效液相色谱法和自动比浊法测定复方口服混悬剂中的磺胺类药物和琥乙红霉素。色谱方法快速、特异，对于乙酰磺胺异恶唑和三磺胺嘧啶，使用反相系统在254nm处进行紫外检测，具有稳定性指示作用。琥乙红霉素不干扰磺胺类药物的分析，这些化合物的测定相对标准偏差（RDS）为±2.1%至±3.1%。琥乙红霉素以红霉素计进行测定，相对标准偏差（RSD）值为±1.3%或3.5%，不受共存磺胺类药物的干扰。
