用H-2同种异体抗原预先免疫的同基因和异基因交配怀孕小鼠体内抗体的水平和分布。
The level and distribution of antibody in syngeneic and allogeneic mated pregnant mice pre-immunized with H-2 alloantigens.
作者信息
Taylor G M
出版信息
Immunology. 1973 Nov;25(5):703-92.
The antibody profile of syngeneic and allogeneic (donor) mated female mice, previously actively immunized with allogeneic spleen cells was measured during pregnancy. Marked differences were found, since syngeneic mated females showed a transient fall in antibody titre, whilst allogeneic mated females showed a strong upsurge in antibody titre, from the last week of pregnancy to well after parturition. The level of alloantibody in the serum of the syngeneic and semi-allogeneic progeny of these matings was markedly different. Immunofluorescent studies on lymphoid cells from the semi-allogeneic progeny of immune females revealed a significant number carrying an immunoglobulin which was concluded to be alloantibody on the basis of control experiments. The differences in maternal alloantibody production profiles were attributed either to an alteration in immunoregulation of antibody synthesis in allogeneic mated females caused by absorption of antibody by the semi-allogeneic progeny , or to secondary response to foetally-derived allogeneic antigens, or the synergistic action of both.
在怀孕期测定了同基因和异基因（供体）交配的雌性小鼠的抗体谱，这些小鼠先前已用异基因脾细胞进行了主动免疫。结果发现了显著差异，因为同基因交配的雌性小鼠抗体滴度出现短暂下降，而异基因交配的雌性小鼠从怀孕最后一周到产后很长时间抗体滴度都出现强烈上升。这些交配产生的同基因和半异基因后代血清中的同种抗体水平明显不同。对免疫雌性小鼠半异基因后代的淋巴细胞进行的免疫荧光研究显示，大量细胞携带一种免疫球蛋白，根据对照实验得出结论，该免疫球蛋白为同种抗体。母体同种抗体产生谱的差异要么归因于半异基因后代吸收抗体导致异基因交配雌性小鼠抗体合成免疫调节的改变，要么归因于对胎儿来源的异基因抗原的二次反应，或者两者的协同作用。
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