排斥反应大鼠肾移植组织切片中的胸腺依赖性淋巴细胞。

Thymus-dependent lymphocytes in tissue sections of rejecting rat renal allografts.

作者信息

Balch C M, Wilson C B, Lee S, Feldman J D

出版信息

J Exp Med. 1973 Dec 1;138(6):1584-90. doi: 10.1084/jem.138.6.1584.

DOI:10.1084/jem.138.6.1584

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2139462/

Abstract

Lewis kidneys were grafted into BN recipients and examined at daily intervals up to 6 days after grafting with immunofluorescent reagents. A horse antiserum specific for T lymphocytes revealed an increasing number of T lymphocytes in the cellular infiltrates of rejecting allografts. These were detectable 1 day after grafting, reached a maximum 3 days later, and were relatively diminished at 6 days. In control isografts and nonimmunological inflammations of kidney, a small number of dispersed T lymphocytes was seen. A rabbit antirat thymocyte antiserum, given to allografted BN rats, prolonged survival of the grafts and decreased the cellular infiltrate and the number of T lymphocytes in the infiltrates. We conclude that in graft rejection there is a flow of T lymphocytes into areas of tissue damage and these T lymphocytes are immunologically reactive to graft antigens.

摘要

将Lewis大鼠的肾脏移植到BN受体体内，并在移植后每隔一天用免疫荧光试剂进行检查，直至移植后6天。一种对T淋巴细胞具有特异性的马抗血清显示，在排斥同种异体移植物的细胞浸润中，T淋巴细胞数量不断增加。移植后1天即可检测到这些细胞，3天后达到峰值，6天时相对减少。在对照同基因移植和肾脏的非免疫性炎症中，可见少量分散的T淋巴细胞。给同种异体移植的BN大鼠注射兔抗大鼠胸腺细胞抗血清，可延长移植物的存活时间，并减少细胞浸润以及浸润中的T淋巴细胞数量。我们得出结论，在移植排斥反应中，T淋巴细胞流入组织损伤区域，并且这些T淋巴细胞对移植抗原具有免疫反应性。

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Dig Dis Sci. 1993 Apr;38(4):619-25. doi: 10.1007/BF01316790.

2

T-cell migration into allografts.T细胞向同种异体移植物的迁移。

J Exp Med. 1975 May 1;141(5):1210-5. doi: 10.1084/jem.141.5.1210.

3

Reassortment of lymphocytes in lymph from normal and allografted sheep.正常绵羊和同种异体移植绵羊淋巴液中淋巴细胞的重排

Am J Pathol. 1977 Apr;87(1):59-80.

本文引用的文献

1

An improved technique of renal transplantation in the rat.大鼠肾移植的一种改良技术。

Surgery. 1967 May;61(5):771-3.

2

Thymus-derived cells in the early phase of delayed tuberculin reactions.迟发型结核菌素反应早期的胸腺来源细胞。

J Immunol. 1969 Dec;103(6):1435-7.

3

Renal homotransplantation in rats. I. Allogeneic recipients.大鼠肾同种移植。I. 同种异体受体。

J Exp Med. 1967 Nov 1;126(5):783-94. doi: 10.1084/jem.126.5.783.

4

Homing of specifically sensitized lymphocytes to allografts of skin.特异性致敏淋巴细胞向同种异体皮肤移植物的归巢。

Cell Immunol. 1972 Sep;5(1):66-73. doi: 10.1016/0008-8749(72)90084-6.

5

In vivo studies of the role of cytotoxic T cells in tumor allograft immunity.细胞毒性T细胞在肿瘤同种异体移植免疫中作用的体内研究。

J Immunol. 1972 Dec;109(6):1371-8.

6

The in vivo activity of in vitro immunized mouse thymocytes. II. Rejection of skin allografts and graft-vs-host activity.体外免疫小鼠胸腺细胞的体内活性。II. 同种异体皮肤移植排斥反应及移植物抗宿主活性。

J Immunol. 1972 Dec;109(6):1282-9.

7

Proportion of T and B lymphocytes in lesions of Marek's disease: theoretical implications for pathogenesis.马立克氏病病变中T淋巴细胞和B淋巴细胞的比例：对发病机制的理论启示

J Immunol. 1973 Feb;110(2):534-9.

8

Functional heterogeneity of murine lymphoid cells. IV. Allogeneic mixed lymphocyte reactivity and cytolytic activity as functions of distinct T cell subsets.小鼠淋巴细胞的功能异质性。IV. 同种异体混合淋巴细胞反应性和细胞溶解活性作为不同T细胞亚群的功能

J Immunol. 1973 Mar;110(3):652-60.

9

Functional heterogeneity of murine lymphoid cells. 3. Differential responsiveness of T cells to phytohemagglutinin and concanavalin A as a probe for T cell subsets.小鼠淋巴细胞的功能异质性。3. T细胞对植物血凝素和刀豆球蛋白A的差异反应性作为T细胞亚群的一种检测方法。

J Immunol. 1973 Feb;110(2):362-75.

10

Functional heterogeneity of murine lymphoid cells. II. Acquisition of mitogen responsiveness and of theta antigen during the ontogeny of thymocytes and "T" lymphocytes.小鼠淋巴细胞的功能异质性。II. 胸腺细胞和 “T” 淋巴细胞个体发育过程中有丝分裂原反应性和θ抗原的获得。

Cell Immunol. 1972 Aug;4(4):367-80. doi: 10.1016/0008-8749(72)90039-1.

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