Balch C M, Wilson C B, Lee S, Feldman J D
J Exp Med. 1973 Dec 1;138(6):1584-90. doi: 10.1084/jem.138.6.1584.
Lewis kidneys were grafted into BN recipients and examined at daily intervals up to 6 days after grafting with immunofluorescent reagents. A horse antiserum specific for T lymphocytes revealed an increasing number of T lymphocytes in the cellular infiltrates of rejecting allografts. These were detectable 1 day after grafting, reached a maximum 3 days later, and were relatively diminished at 6 days. In control isografts and nonimmunological inflammations of kidney, a small number of dispersed T lymphocytes was seen. A rabbit antirat thymocyte antiserum, given to allografted BN rats, prolonged survival of the grafts and decreased the cellular infiltrate and the number of T lymphocytes in the infiltrates. We conclude that in graft rejection there is a flow of T lymphocytes into areas of tissue damage and these T lymphocytes are immunologically reactive to graft antigens.
将Lewis大鼠的肾脏移植到BN受体体内，并在移植后每隔一天用免疫荧光试剂进行检查，直至移植后6天。一种对T淋巴细胞具有特异性的马抗血清显示，在排斥同种异体移植物的细胞浸润中，T淋巴细胞数量不断增加。移植后1天即可检测到这些细胞，3天后达到峰值，6天时相对减少。在对照同基因移植和肾脏的非免疫性炎症中，可见少量分散的T淋巴细胞。给同种异体移植的BN大鼠注射兔抗大鼠胸腺细胞抗血清，可延长移植物的存活时间，并减少细胞浸润以及浸润中的T淋巴细胞数量。我们得出结论，在移植排斥反应中，T淋巴细胞流入组织损伤区域，并且这些T淋巴细胞对移植抗原具有免疫反应性。
