大鼠同种异体肾移植的免疫增强。I. 急性排斥和被动增强移植肾的比较形态学。

Abbas A K, Corson J M, Carpenter C B, Galvanek E G, Merrill J P, Dammin G J

Am J Pathol. 1974 May;75(2):255-70.

The acute unmodified rejection of (Lewis x Brown Norway) F(1) to Lewis renal allografts is characterized by an early and progressive lymphoid cell infiltrate, glomerular necrosis, necrotizing arteritis and ischemic cortical necrosis leading to graft destruction. A single low dose of enhancing antiserum given at the time of transplantation prolongs graft survival by abrogating the necrotizing lesions in glomeruli and arteries and the subsequent cortical necrosis. Passive enhancement in this model is interpreted as representing predominantly a block in the humoral antibody-mediated rejection response. It is suggested that the block is effected mainly, peripherally, ie, at the level of the transplanted kidney itself.

（Lewis×Brown Norway）F1 对 Lewis 肾移植的急性未修饰排斥反应的特征是早期进行性淋巴细胞浸润、肾小球坏死、坏死性动脉炎和缺血性皮质坏死，最终导致移植物破坏。移植时给予单次低剂量增强抗血清可通过消除肾小球和动脉中的坏死性病变以及随后的皮质坏死来延长移植物存活时间。该模型中的被动增强主要被解释为体液抗体介导的排斥反应受阻。有人提出，这种阻断主要在周围起作用，即在移植肾本身的水平上。