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大鼠同种异体肾移植的免疫增强。I. 急性排斥和被动增强移植肾的比较形态学。

Immunologic enhancement of rat renal allografts. I. Comparative morphology of acutely rejecting and passively enhanced grafts.

作者信息

Abbas A K, Corson J M, Carpenter C B, Galvanek E G, Merrill J P, Dammin G J

出版信息

Am J Pathol. 1974 May;75(2):255-70.

PMID:4595938
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1910827/
Abstract

The acute unmodified rejection of (Lewis x Brown Norway) F(1) to Lewis renal allografts is characterized by an early and progressive lymphoid cell infiltrate, glomerular necrosis, necrotizing arteritis and ischemic cortical necrosis leading to graft destruction. A single low dose of enhancing antiserum given at the time of transplantation prolongs graft survival by abrogating the necrotizing lesions in glomeruli and arteries and the subsequent cortical necrosis. Passive enhancement in this model is interpreted as representing predominantly a block in the humoral antibody-mediated rejection response. It is suggested that the block is effected mainly, peripherally, ie, at the level of the transplanted kidney itself.

摘要

（Lewis×Brown Norway）F1 对 Lewis 肾移植的急性未修饰排斥反应的特征是早期进行性淋巴细胞浸润、肾小球坏死、坏死性动脉炎和缺血性皮质坏死，最终导致移植物破坏。移植时给予单次低剂量增强抗血清可通过消除肾小球和动脉中的坏死性病变以及随后的皮质坏死来延长移植物存活时间。该模型中的被动增强主要被解释为体液抗体介导的排斥反应受阻。有人提出，这种阻断主要在周围起作用，即在移植肾本身的水平上。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5522/1910827/450aa646848d/amjpathol00475-0060-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5522/1910827/9916c3c10bfd/amjpathol00475-0057-a.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5522/1910827/781c2f7baa38/amjpathol00475-0058-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5522/1910827/e6e4ef8b376f/amjpathol00475-0058-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5522/1910827/78c2c3842058/amjpathol00475-0059-a.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5522/1910827/e353a0a3825d/amjpathol00475-0060-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5522/1910827/450aa646848d/amjpathol00475-0060-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5522/1910827/9916c3c10bfd/amjpathol00475-0057-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5522/1910827/d639be8d6149/amjpathol00475-0057-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5522/1910827/781c2f7baa38/amjpathol00475-0058-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5522/1910827/e6e4ef8b376f/amjpathol00475-0058-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5522/1910827/78c2c3842058/amjpathol00475-0059-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5522/1910827/4ac58c45a576/amjpathol00475-0059-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5522/1910827/e353a0a3825d/amjpathol00475-0060-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5522/1910827/450aa646848d/amjpathol00475-0060-b.jpg

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引用本文的文献

1
Immunologic enhancement of rat renal allografts. II. Immunohistology of acutely rejecting and passively enhanced grafts.大鼠肾同种异体移植的免疫增强作用。II. 急性排斥和被动增强移植的免疫组织学
Am J Pathol. 1974 May;75(2):271-84.
2
Immunologic enhancement of rat renal allografts. III. Immunopathologic lesions and rejection in long-surviving passively enhanced grafts.大鼠肾同种异体移植的免疫增强作用。III. 长期存活的被动增强移植肾中的免疫病理损伤与排斥反应
Am J Pathol. 1975 May;79(2):255-70.
3
The combined use of antilymphocyte serum and cyclophosphamide to suppress renal allograft rejection in the rat.

本文引用的文献

1
Human renal allografts. The role of vascular injury in early graft failure.人类肾移植。血管损伤在早期移植失败中的作用。
Medicine (Baltimore). 1971 Jan;50(1):29-83.
2
Allogeneic "rejection" of in situ rat kidney using humoral antibody.
Transplant Proc. 1971 Mar;3(1):570-2.
3
Renal transplantation in the inbred rat. VI. Electron microscopic study of the mononuclear cells accumulating in rejecting renal allografts.近交系大鼠的肾移植。VI. 对排斥反应中肾同种异体移植内积聚的单核细胞的电子显微镜研究。
联合使用抗淋巴细胞血清和环磷酰胺抑制大鼠肾移植排斥反应。
Clin Exp Immunol. 1979 Feb;35(2):242-9.
4
Successful cardiac allografts in syngeneic radiation chimeras.同基因辐射嵌合体中成功的心脏同种异体移植。
Mol Cell Biochem. 1978 Nov 1;21(2):83-94. doi: 10.1007/BF00240279.
5
The role of nonclassical Fc receptor-associated, Ag-B antigens (Ia) in rat allograft enhancement.非经典Fc受体相关的Ag-B抗原（Ia）在大鼠同种异体移植增强中的作用。
J Exp Med. 1976 Feb 1;143(2):405-21. doi: 10.1084/jem.143.2.405.
Transplantation. 1971 Jul;12(1):1-10.
4
Hyperacute cortical necrosis after antibody pretreatment of syngeneic rat kidney transplants.同基因大鼠肾移植抗体预处理后的超急性皮质坏死
Scand J Urol Nephrol. 1970;4(1):58-65. doi: 10.3109/00365597009136229.
5
Immunologic enhancement of renal allografts in the rat. I. Dissociation of graft survival and antibody response.大鼠同种异体肾移植的免疫增强作用。I. 移植肾存活与抗体反应的分离
Fed Proc. 1970 Nov-Dec;29(6):2041-7.
6
Renal transplantation in the inbred rat. 13. Modification of rejection by active immunization with bone marrow cells.近交系大鼠的肾移植。13. 用骨髓细胞主动免疫对排斥反应的改良。
Transplantation. 1970 Jan;9(1):30-8.
7
Rejection of renal allografts: specific immunologic suppression.同种异体肾移植排斥反应：特异性免疫抑制
Science. 1968 Jun 28;160(3835):1463-5. doi: 10.1126/science.160.3835.1463.
8
Renal homotransplantation in rats. I. Allogeneic recipients.大鼠肾同种移植。I. 同种异体受体。
J Exp Med. 1967 Nov 1;126(5):783-94. doi: 10.1084/jem.126.5.783.
9
Immunologic enhancement of rat renal allografts. II. Immunohistology of acutely rejecting and passively enhanced grafts.大鼠肾同种异体移植的免疫增强作用。II. 急性排斥和被动增强移植的免疫组织学
Am J Pathol. 1974 May;75(2):271-84.
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The pathologist and the kidney transplant.病理学家与肾移植
Pathol Annu. 1972;7:251-92.