大鼠氰化物中毒：生理和神经病理学方面

Brierley J B, Brown A W, Calverley J

J Neurol Neurosurg Psychiatry. 1976 Feb;39(2):129-40. doi: 10.1136/jnnp.39.2.129.

Sodium cyanide was given to rats by intravenous infusion at a rate that would avert apnoea (the first sign of overdosage) in the majority. There was full physiological monitoring in a group under anaesthesia and more limited monitoring in an unanaesthetized group. White matter was damaged in six animals and grey matter additionally in only one. It was concluded that cyanide can damage neurones only through the medium of secondary effects on circulation and respiration.

通过静脉输注的方式，以能避免大多数大鼠出现呼吸暂停（过量用药的首个迹象）的速率给大鼠注射氰化钠。一组处于麻醉状态下的大鼠接受了全面的生理监测，而未麻醉组的监测则较为有限。六只动物的白质受到损伤，只有一只动物的灰质也受到了损伤。研究得出结论，氰化物只能通过对循环和呼吸产生的继发效应来损伤神经元。