Kim C U, Misco P F, McGregor D N
J Med Chem. 1979 Jun;22(6):743-5. doi: 10.1021/jm00192a025.
The first reported synthesis of 2-oxocephalosporin derivatives has been achieved via ozonolysis of the corresponding 2-methylenecephalosporins. The new cephalosporin derivatives showed some antibacterial activity against Gram-positive bacteria, but the 2-oxo analogue of cephalothin was much less active than cephalothin itself.
首次报道的2-氧代头孢菌素衍生物的合成是通过相应的2-亚甲基头孢菌素的臭氧分解实现的。新的头孢菌素衍生物对革兰氏阳性菌显示出一定的抗菌活性，但头孢噻吩的2-氧代类似物的活性远低于头孢噻吩本身。
