Abu-Aisha H, Abu-Sabaa H M, Nur T
J Trop Med Hyg. 1979 Feb;82(2):36-7.
In cases of severe malaria chloroquine phosphate is frequently given--diluted or undiluted--by the intravenous route. It is known that cardiac arrhythmias and hypotension may complicate such therapy, but cardiac arrest is not a well recognised hazard. In this report we describe such a tragic complication, and advocate that undiluted chloroquine should not be administered intravenously in severely ill patients since such patients usually have associated electrolyte disturbances which may render the heart vulnerable to toxic drugs. Chloroquine may be given diluted in normal saline infused over several hours with a close watch over the blood pressure.
在严重疟疾的病例中，磷酸氯喹常常通过静脉途径给药——稀释或未稀释的。已知心律失常和低血压可能使这种治疗复杂化，但心脏骤停并非广为人知的风险。在本报告中，我们描述了这样一种悲惨的并发症，并主张在重症患者中不应静脉注射未稀释的氯喹，因为这类患者通常伴有电解质紊乱，这可能使心脏对毒性药物更易产生不良反应。氯喹可以用生理盐水稀释后在数小时内输注，并密切监测血压。
