elZaki K, Ahmed M E, elHassan A M, Yousif M A, Fahal A H
Khartoum Teaching Hospital, University of Khartoum, Sudan.
J Trop Med Hyg. 1991 Jun;94(3):206-9.
This prospective study contains clinical and experimental parts. In the clinical study, 125 patients given intramuscular chloroquine for malaria were followed for 2 months in order to detect local injection site complications. Adequate local antiseptic conditions were ensured before giving the injection. Twenty-three patients (18.4%) had minimal local reaction in the form of redness, induration and/or a lump. No pyogenic abscess was noted in contrast to a previous report. In the second part of the study, an experimental animal (Green monkey) was given either chloroquine phosphate, Ampiclox or normal saline intramuscularly. The injection site was later biopsied and histologically examined. Intramuscular chloroquine was found to cause severe inflammatory reactions and muscle necrosis, whereas other injections had very minimal local effects. It is concluded that intramuscular chloroquine causes muscle necrosis which may lead to acute pyogenic abscess if minimal contamination takes place.
这项前瞻性研究包括临床和实验两个部分。在临床研究中，对125名接受肌肉注射氯喹治疗疟疾的患者进行了为期2个月的随访，以检测局部注射部位的并发症。在注射前确保了适当的局部消毒条件。23名患者（18.4%）出现了以发红、硬结和/或肿块形式的轻微局部反应。与之前的报告相比，未发现脓性脓肿。在研究的第二部分，对一只实验动物（绿猴）肌肉注射磷酸氯喹、氨苄青霉素或生理盐水。随后对注射部位进行活检并进行组织学检查。发现肌肉注射氯喹会引起严重的炎症反应和肌肉坏死，而其他注射的局部影响非常小。得出的结论是，肌肉注射氯喹会导致肌肉坏死，如果发生轻微污染，可能会导致急性脓性脓肿。
