普萘洛尔对缺血性心脏病患者静息及运动时左心室功能的影响。

The effect of propranolol on left ventricular function at rest and during exercise in patients with ischemic heart disease.

作者信息

Jebavý P, Ressl J, Jandová R

出版信息

Jpn Heart J. 1979 May;20(3):261-70. doi: 10.1536/ihj.20.261.

DOI:10.1536/ihj.20.261

Abstract

Twelve patients with ischemic heart disease were investigated by right and left heart catheterisation. All patients were studied at rest and during exercise, both before and after administration of beta-blocker propranolol, Inderal (ICI). Left ventricular function decreased after administration of propranolol, but these changes were significant only during exercise. Contractility was depressed after administration of propranolol already at rest. On the other hand, left ventricular filling pressure decreased after administration of propranolol. Our results show the poor reliability of the evaluation of the left ventricular function based solely on the left ventricular filling pressure.

摘要

对12例缺血性心脏病患者进行了右心和左心导管检查。所有患者均在静息状态和运动状态下进行研究，且在给予β受体阻滞剂普萘洛尔（心得安，ICI公司生产）之前和之后都进行了研究。给予普萘洛尔后左心室功能下降，但这些变化仅在运动时显著。在静息状态下给予普萘洛尔后收缩性就已降低。另一方面，给予普萘洛尔后左心室充盈压下降。我们的结果表明仅基于左心室充盈压来评估左心室功能的可靠性较差。

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