盐酸金刚烷胺（Symmetrel）治疗急性带状疱疹
Treatment of acute herpes zoster with amantadine hydrochloride (Symmetrel).
作者信息
Galbraith A W
出版信息
Br Med J. 1973 Dec 22;4(5894):693-5. doi: 10.1136/bmj.4.5894.693.
Abstract
A double-blind, placebo-controlled trial of amantadine hydrochloride (Symmetrel) in acute herpes zoster (shingles) was carried out in 100 patients in general practice. The cases were serologically proved. There was no difference in duration of pain between the drug and placebo groups when pain disappeared during the 28 days' observation period. However, pain lasted more than 28 days in a significantly greater proportion of patients receiving placebo than of those on amantadine. Patients with pain after the 28-day observation period were significantly older than those whose pain disappeared during the study. The drug had no effect on rate of healing or appearance of new lesions.
摘要
在100名普通科患者中进行了一项关于盐酸金刚烷胺（Symmetrel）治疗急性带状疱疹（缠腰龙）的双盲、安慰剂对照试验。这些病例经血清学证实。在28天的观察期内疼痛消失时，药物组和安慰剂组的疼痛持续时间没有差异。然而，接受安慰剂的患者中疼痛持续超过28天的比例明显高于服用金刚烷胺的患者。28天观察期后仍有疼痛的患者明显比研究期间疼痛消失的患者年龄大。该药物对愈合速度或新皮损的出现没有影响。
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