Pappenheimer J R
Johns Hopkins Med J. 1979 Aug;145(2):49-56.
A sleep promoting factor has been extracted and purified from cerebrospinal fluid of sleep-deprived goats, from whole brains of sleep-deprived rabbits and from brainstems of slaughterhouse cattle. Intraventricular infusion of the purified material into rats, cats, rabbits or squirrel monkeys induces excess slow-wave sleep in the recipients for several hours following the infusion. The excess sleep appears similar to the deep slow-wave sleep which normally follows sleep deprivation; it is characterized by EEG slow waves of greater than normal amplitude and an increase in both the number and duration of sleep episodes. The sleep factor appears to be a small peptide of molecular weight 350--500 daltons and the effective dose is of the order of a few picomols per gram brain. A similar, perhaps identical, factor is present in human urine.
一种促进睡眠的因子已从睡眠剥夺山羊的脑脊液、睡眠剥夺兔子的全脑以及屠宰场牛的脑干中提取并纯化出来。将纯化后的物质脑室内注入大鼠、猫、兔子或松鼠猴体内，在注入后的几个小时内会使受体出现过量的慢波睡眠。这种过量睡眠与通常在睡眠剥夺后出现的深度慢波睡眠相似；其特征是脑电图慢波的幅度大于正常，睡眠发作的次数和持续时间均增加。睡眠因子似乎是一种分子量为350 - 500道尔顿的小肽，有效剂量约为每克脑几皮摩尔。人尿中也存在一种类似的、可能相同的因子。
