Krueger J M, Pappenheimer J R, Karnovsky M L
Proc Natl Acad Sci U S A. 1982 Oct;79(19):6102-6. doi: 10.1073/pnas.79.19.6102.
A muramyl peptide that induces excess slow-wave sleep in rats, rabbits, and cats has recently been isolated from human urine. We now report that synthetic acetylmuramyl-L-alanyl-D-isoglutamine ("muramyl dipeptide") and its lysyl derivative (acetylmuramyl-L-alanyl-D-isoglutaminyllysine) can mimic the somnogenic effects of the natural peptide. Both compounds are also pyrogenic and may cause other disturbances of autonomic function. The pyrogenic effects of intravenously administered muramyl dipeptide can be suppressed by previous treatment with acetaminophen without blocking the sleep-promoting effects.
最近从人尿中分离出一种能在大鼠、兔子和猫身上诱发过度慢波睡眠的胞壁酰肽。我们现在报告，合成的乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺（“胞壁酰二肽”）及其赖氨酰衍生物（乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺基赖氨酸）可模拟天然肽的促睡眠作用。这两种化合物也有发热作用，并可能引起自主神经功能的其他紊乱。静脉注射胞壁酰二肽的发热作用可被事先用对乙酰氨基酚治疗所抑制，而不影响其促睡眠作用。
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