Sidorenko M I, Semenovich N I, Kalikshteĭn D B
Kardiologiia. 1979 Jun;19(6):22-7.
Observation of 40 patients with drug myocarditis developing in the presence of acute manifestations of drug allergy, and morphological examination of the myocardium of 15 patients who had died of different manifestations of allergy and drug myocarditis show that drug myocarditis develops quite often in acute manifestations of allergy. This is confirmed by the clinical symptoms, the electrocardiographic findings and the results of immunological study with the use of the leukocyte migration inhibition test with the cardiac antigen. In contrast to persons of the control groups, patients with drug myocarditis showed positive results beginning with the 4th-5th day of the development of the pathological process in the myocardium. The migration index was 40.6% on the average (normal value 80%). The morphological findings indicated the development of delayed and immediate allergic processes in the heart manifested by reaction of the myocardiocytes, stroma and vessels. The degree of severity and character of the morphological changes corresponded to the clinical picture of myocarditis.
对40例在药物过敏急性表现情况下发生药物性心肌炎的患者进行观察，并对15例死于不同过敏表现和药物性心肌炎患者的心肌进行形态学检查，结果显示药物性心肌炎常发生于过敏急性表现时。这一点通过临床症状、心电图检查结果以及使用心脏抗原进行白细胞迁移抑制试验的免疫学研究结果得到证实。与对照组人员相比，药物性心肌炎患者从心肌病理过程发展的第4 - 5天开始就显示出阳性结果。迁移指数平均为40.6%（正常值为80%）。形态学检查结果表明心脏出现了迟发性和速发性过敏反应，表现为心肌细胞、基质和血管的反应。形态学变化的严重程度和特征与心肌炎的临床表现相符。
