Coalson J J, Kastl D G, Whalen M H, Greenfield L G
Am J Pathol. 1974 Mar;74(3):533-50.
Induction of chronic pulmonary hypertension in dogs treated by lung allotrans-plantation was performed in this study. Eight adult dogs, 3 mongrels and 5 purebred sibling foxhounds matched by mixed leukocyte culture, comprised group I and were subjected to recurrent macroembolization and compared to another group (II) of 8 unmatched normotensive animals who received allografts and immunosuppressive therapy. Findings in early biopsy specimens in the group I animals revealed endothelial edema. A mononuclear vasculitis, more marked around the veins, and a mononuclear chronic inflammatory infiltrate in the bronchial wall were additional findings in the early biopsy specimens. In the group I late biopsy specimens, electron-dense and electron-lucent endothelial cells and multilamination of the basement membrane were characteristic features. Fibrosis of the bronchial wall structures was noted during this time period, as was alveolar wall fibrosis. These pathologic endothelial lesions, the basement membrane multi-lamination and the alveolar wall fibrosis are similar to the lesions reported in the chronically rejected renal allograft.
本研究对接受肺同种异体移植治疗的犬进行慢性肺动脉高压诱导。8只成年犬，其中3只为杂种犬，5只为通过混合白细胞培养匹配的纯种同胞猎狐犬，组成I组，接受反复大栓塞，并与另一组8只未匹配的血压正常的动物（II组）进行比较，II组动物接受同种异体移植和免疫抑制治疗。I组动物早期活检标本的结果显示内皮水肿。早期活检标本中的其他发现包括单核细胞性血管炎，在静脉周围更明显，以及支气管壁的单核细胞慢性炎症浸润。在I组晚期活检标本中，电子致密和电子透亮的内皮细胞以及基底膜的多层化是特征性表现。在此期间注意到支气管壁结构的纤维化以及肺泡壁纤维化。这些病理性内皮病变、基底膜多层化和肺泡壁纤维化与慢性排斥肾同种异体移植中报道的病变相似。
