大疱性类天疱疮体内结合免疫球蛋白的超微结构定位——初步报告
Ultrastructural localization of in vivo bound immunoglobulins in bullous pemphigoid--a preliminary report.
作者信息
Schaumburg-Lever G, Rule A, Schmidt-Ullrich R, Lever W F
出版信息
J Invest Dermatol. 1975 Jan;64(1):47-9. doi: 10.1111/1523-1747.ep12540902.
PMID:45929
Abstract
The ultrastructural location of in vivo bound immunoglobulins in a case of bullous pemphigoid was determined by coupling peroxidase to antihuman gamma globulin. Immunoglobulin deposits were found exclusively in the space between the basal cells and the basal lamina. The location of the immunoglobulin in bullous pemphigoid thus differs from that in lupus erythematosus where immunoglobulins are found mainly below the basal lamina.
摘要
通过将过氧化物酶与抗人γ球蛋白偶联，确定了一例大疱性类天疱疮病例中体内结合免疫球蛋白的超微结构位置。免疫球蛋白沉积物仅在基底细胞和基底层之间的间隙中发现。因此，大疱性类天疱疮中免疫球蛋白的位置与红斑狼疮不同，红斑狼疮中的免疫球蛋白主要在基底层下方发现。
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