特布他林与沙丁胺醇气雾剂对可逆性气道阻塞患者心肺效应的比较
Comparison of cardiorespiratory effects of terbutaline and salbutamol aerosols in patients with reversible airways obstruction.
作者信息
Harris L
出版信息
Thorax. 1973 Sep;28(5):592-5. doi: 10.1136/thx.28.5.592.
Abstract
, , 592-595. The effects of pressurized aerosol administration of terbutaline were compared with those of salbutamol in 14 patients with at least 20% reversibility of airways obstruction. The two drugs were found to be equipotent bronchodilators in the dosage used. Salbutamol was found to produce significant increases in minute ventilation, physiological dead space/tidal volume ratio, and ventilatory equivalent for oxygen, with significant falls in arterial oxygen tension and heart rate. Terbutaline did not induce significant changes in any of these variables. These results suggest that terbutaline is less likely than salbutamol to have an adverse effect upon ventilation-perfusion relationships.
摘要
（页码）592 - 595。在14例气道阻塞至少有20%可逆性的患者中，比较了特布他林加压气雾剂给药与沙丁胺醇给药的效果。发现两种药物在所使用的剂量下是等效的支气管扩张剂。发现沙丁胺醇可使分钟通气量、生理无效腔/潮气量比值及氧通气当量显著增加，同时动脉血氧张力和心率显著下降。特布他林在这些变量中均未引起显著变化。这些结果表明，与沙丁胺醇相比，特布他林对通气 - 灌注关系产生不良反应的可能性较小。
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