两种口服选择性β2肾上腺素能兴奋剂药物在支气管哮喘中的比较。
Comparison of two oral selective beta2-adrenergic stimulant drugs in bronchial asthma.
作者信息
Legge J S, Gaddie J, Palmer K N
出版信息
Br Med J. 1971 Mar 20;1(5750):637-9. doi: 10.1136/bmj.1.5750.637.
Abstract
The effect of two oral selective beta(2)-stimulant drugs, salbutamol and terbutaline, on spirometry, arterial blood-gas tensions, pulse, and blood pressure was compared with placebo in a double-blind controlled trial in 12 asthmatic patients. Both drugs increased to forced vital capacity and the forced expiratory volume in 1 second equally for up to five hours, the maximal effect occurring at two to four hours. There was no significant change in arterial blood-gas tensions but both drugs increased pulse rate slightly. Tremor was the most common side effect. Terbutaline seems to be an effective alternative to salbutamol.
摘要
在一项针对12名哮喘患者的双盲对照试验中，将两种口服选择性β₂激动剂药物沙丁胺醇和特布他林对肺活量测定、动脉血气张力、脉搏和血压的影响与安慰剂进行了比较。两种药物在长达5小时内均能同等程度地增加用力肺活量和1秒用力呼气量，最大效应出现在2至4小时。动脉血气张力无显著变化，但两种药物均使脉搏率略有增加。震颤是最常见的副作用。特布他林似乎是沙丁胺醇的一种有效替代药物。
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