Thacker L, Brooks J B
Infect Immun. 1974 Apr;9(4):648-53. doi: 10.1128/iai.9.4.648-653.1974.
N-nitrosodimethylamine, a potent carcinogen, was produced by three strains each of Proteus mirabilis, P. morganii, and P. rettgeri, but not by three strains of P. vulgaris grown under the same conditions. Many of the alkaline-extractable volatile metabolites elaborated by these organisms are the same, but there are some qualitative and quantitative differences among species. Representative gas-liquid chromatographic profiles of the four species are presented, and the significance of the differences is discussed. Primary emphasis, however, is given to the importance of the production of N-nitrosodimethylamine by these microorganisms and the conditions under which it is produced.
N-亚硝基二甲胺是一种强效致癌物，奇异变形杆菌、摩根氏菌和雷氏普罗威登斯菌的三个菌株均能产生该物质，但在相同条件下培养的普通变形杆菌的三个菌株则不能产生。这些微生物所产生的许多可碱提取挥发性代谢物是相同的，但不同菌种之间存在一些质和量的差异。文中给出了这四种菌的代表性气-液色谱图，并讨论了这些差异的意义。然而，重点强调的是这些微生物产生N-亚硝基二甲胺的重要性以及产生该物质的条件。
