Abbas A K, Corson J M, Carpenter C B, Galvanek E G, Merrill J P, Dammin G J
Am J Pathol. 1974 May;75(2):271-84.
Unmodified renal transplants from (Lewis x Brown Norway) F(1) hybrids to Lewis rats show deposition of immunoglobulin (IgG) and complement in the arteries, which cause an acute necrotizing arteritis with ischemic necrosis of the grafts. Treatment with a single dose of enhancing antiserum at the time of transplantation prevents the arterial deposition of IgG and complement, and the vascular lesions. The enhancing antibody probably acts peripherally by blocking crucial antigenic sites in the graft vasculature, since cytotoxic alloantibody is detectable in the circulation of both control and enhanced recipients. Unmodified allografts also show deposition of IgG in glomeruli accompanied by glomerular necrosis. Immunofluorescent studies indicate that these glomerular lesions are mediated by complexes of antigen and alloantibody, and at least partially also by a nonhistocompatibility antibody directed against antigens in glomerular endothelial cells. Enhancing antiserum treatment reduces glomerular IgG deposition and thus greatly mitigates the glomerular lesion as well.
将（Lewis×Brown Norway）F1杂种的未修饰肾移植到Lewis大鼠体内，会出现免疫球蛋白（IgG）和补体在动脉中的沉积，这会导致急性坏死性动脉炎并伴有移植物的缺血性坏死。在移植时用单剂量增强抗血清治疗可防止IgG和补体在动脉中的沉积以及血管病变。增强抗体可能通过阻断移植物脉管系统中的关键抗原位点在周围起作用，因为在对照受体和增强受体的循环中均可检测到细胞毒性同种异体抗体。未修饰的同种异体移植物还显示IgG在肾小球中的沉积并伴有肾小球坏死。免疫荧光研究表明，这些肾小球病变是由抗原和同种异体抗体的复合物介导的，并且至少部分也是由针对肾小球内皮细胞中抗原的非组织相容性抗体介导的。增强抗血清治疗可减少肾小球IgG沉积，从而也大大减轻了肾小球病变。
