López Encuentra A, Martínez González del Río J, Pérez Rodríguez E
Med Clin (Barc). 1979 May 10;72(9):361-8.
The Bronchogenic Carcinoma Co-operative Group analyzed the epidemiologic data of 240 cases of bronchogenic carcinoma in a prospective study. When risk factors (exposure to potencial pathogenic substances) were studied, a relationship was noted between the incidence at an early age and the presence of nondifferentiated small cell carcinoma. The number of years of exposure to tobacco had a direct effect on the curative value of the thoracotomy and the survival rate. Forty years of smoking appeared to be borderline for a poor prognosis. Localization of the tumor by bronchoscopy showed a frequency in the left main bronchus (18 percent) more than twice than in the right (8 percent). In 25 percent of the cases the tumor was more peripheral than the subsegmental situation according to the bronchofiberoptic examination. Evaluation of clinical data only showed a lack of correlation between the different symptoms and the various means of evaluation and the prognosis of the disease. For example, a patient with hemoptysis has a statistically higher probability of having an epidermoid tumor and a greater possibility of a successful curative thoracotomy (23 percent as opposed to 17 percent for the rest). The group of incidental cases (9 percent of the total) was analyzed. The degree of resectability was higher as compared with the rest (62 percent against 34 percent) as well as the absence of nondifferentiated small cell type carcinomas.
支气管癌协作组在一项前瞻性研究中分析了240例支气管癌的流行病学数据。在研究危险因素（接触潜在致病物质）时，发现早年发病与未分化小细胞癌的存在之间存在关联。吸烟年限对开胸手术的治疗价值和生存率有直接影响。吸烟40年似乎是预后不良的临界值。通过支气管镜检查确定肿瘤位置显示，肿瘤在左主支气管的发生率（18%）是右主支气管（8%）的两倍多。根据纤维支气管镜检查，25%的病例中肿瘤比亚段情况更靠近周边。仅对临床数据进行评估显示，不同症状、各种评估手段与疾病预后之间缺乏相关性。例如，咯血患者患表皮样肿瘤的统计学概率更高，开胸手术成功治愈的可能性更大（23%，其余患者为17%）。对偶然发现病例组（占总数的9%）进行了分析。与其他病例相比，其可切除程度更高（62%对34%），且未分化小细胞癌类型不存在。
