间歇性正压通气给予瑞米特罗和沙丁胺醇气雾剂后的反应。
Response to rimiterol and salbutamol aerosols administered by intermittent positive-pressure ventilation.
作者信息
Cooke N J, Kerr J A, Willey R F, Hoare M V, Grant I W, Cromptom G K
出版信息
Br Med J. 1974 May 4;2(5913):250-2. doi: 10.1136/bmj.2.5913.250.
The bronchodilator and cardiac effects produced by aerosols of 0.5% salbutamol and 0.5% and 1% rimiterol administered for three minutes in 40% oxygen by intermittent positive-pressure ventilation (I.P.P.V.) were compared in 15 asthmatic patients. Salbutamol and both the concentrations of rimiterol were equipotent in peak bronchodilator effect, but salbutamol had a significantly longer duration of bronchodilator action. There was significantly less increase in heart rate after rimiterol than after salbutamol. Aerosols of 0.5% rimiterol, 0.5% salbutamol, and saline were administered by I.P.P.V. to 10 normal volunteers. There was no difference between the mean heart rates after 0.5% rimiterol and saline but a highly significant increase in mean heart rate was observed after 0.5% salbutamol. It was concluded that 0.5% rimiterol was an effective short-acting bronchodilator drug with little or no cardiac beta(1)-adrenergic activity when administered for three minutes by I.P.P.V. in 40% oxygen.
在15名哮喘患者中，比较了通过间歇性正压通气（I.P.P.V.）给予40%氧气中0.5%沙丁胺醇气雾剂以及0.5%和1%利米特罗气雾剂三分钟所产生的支气管扩张和心脏效应。沙丁胺醇以及两种浓度的利米特罗在支气管扩张峰值效应方面等效，但沙丁胺醇的支气管扩张作用持续时间显著更长。利米特罗给药后心率的增加显著低于沙丁胺醇给药后。通过I.P.P.V.向10名正常志愿者给予0.5%利米特罗、0.5%沙丁胺醇和生理盐水气雾剂。0.5%利米特罗和生理盐水给药后的平均心率之间无差异，但0.5%沙丁胺醇给药后观察到平均心率有高度显著的增加。得出的结论是，当在40%氧气中通过I.P.P.V.给药三分钟时，0.5%利米特罗是一种有效的短效支气管扩张药物，几乎没有或没有心脏β(1) - 肾上腺素能活性。
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