气雾剂递送的支气管扩张剂药物的临床评估
Clinical assessment of bronchodilator drugs delivered by aerosol.
作者信息
Shenfield G M, Paterson J W
出版信息
Thorax. 1973 Mar;28(2):124-8. doi: 10.1136/thx.28.2.124.
Abstract
A method is described for the early clinical evaluation of bronchodilator aerosols. It is simple to perform, and an accurate estimate of potency can be obtained in a small number of patients. Using this method, three new sympathomimetic drugs, Th 1165a, salmefamol, and rimiterol, have been tested. All proved to be active bronchodilators and were equipotent with isoprenaline or salbutamol.
摘要
本文描述了一种用于支气管扩张气雾剂早期临床评估的方法。该方法操作简单，在少数患者中即可获得对药效的准确估计。使用这种方法，对三种新型拟交感神经药物Th 1165a、沙美特罗和瑞米特罗进行了测试。结果证明，它们均为有效的支气管扩张剂，且与异丙肾上腺素或沙丁胺醇等效。
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本文引用的文献
1
PATTERNS OF RESPONSE TO BRONCHODILATOR IN YOUNG PATIENTS WITH ASTHMA.年轻哮喘患者对支气管扩张剂的反应模式
Australas Ann Med. 1963 Aug;12:216-20. doi: 10.1111/imj.1963.12.3.216.
2
A comparison of spirometric and peak expiratory flow measurements in men with and without chronic bronchitis.慢性支气管炎患者与非慢性支气管炎患者肺活量测定和呼气峰值流量测量的比较。
Thorax. 1962 Jun;17(2):168-74. doi: 10.1136/thx.17.2.168.
3
The response to bronchodilators in intrinsic asthma.内源性哮喘对支气管扩张剂的反应。
Q J Med. 1961 Apr;30:189-99.
4
Forced expiratory volume before and after isoprenaline.异丙肾上腺素前后的用力呼气量
Thorax. 1957 Sep;12(3):276-8. doi: 10.1136/thx.12.3.276.
5
6
Comparison of cardiorespiratory effects of isoprenaline and salbutamol in patients with bronchial asthma.支气管哮喘患者中异丙肾上腺素与沙丁胺醇心肺效应的比较。
Br Med J. 1970 Jan 10;1(5688):65-70.
7
Effects of salbutamol and isoprenaline-phenylephrine in reversible airways obstruction.沙丁胺醇与异丙肾上腺素-去氧肾上腺素对可逆性气道阻塞的作用
Br Med J. 1972 Feb 26;1(5799):539-42. doi: 10.1136/bmj.1.5799.539.
8
Trial of new bronchodilator, terbutaline, in asthma.新型支气管扩张剂特布他林治疗哮喘的试验。
Br Med J. 1971 Mar 20;1(5750):633-6. doi: 10.1136/bmj.1.5750.633.
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Trial of bronchodilator drugs given by metered aerosol with a comparison of two bedside methods of estimating airway resistance.定量气雾剂给予支气管扩张剂药物的试验以及两种估算气道阻力的床边方法的比较。
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10
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Lancet. 1968 Aug 24;2(7565):426-9. doi: 10.1016/s0140-6736(68)90467-4.
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