Shenfield G M, Paterson J W
Thorax. 1973 Mar;28(2):124-8. doi: 10.1136/thx.28.2.124.
A method is described for the early clinical evaluation of bronchodilator aerosols. It is simple to perform, and an accurate estimate of potency can be obtained in a small number of patients. Using this method, three new sympathomimetic drugs, Th 1165a, salmefamol, and rimiterol, have been tested. All proved to be active bronchodilators and were equipotent with isoprenaline or salbutamol.
本文描述了一种用于支气管扩张气雾剂早期临床评估的方法。该方法操作简单，在少数患者中即可获得对药效的准确估计。使用这种方法，对三种新型拟交感神经药物Th 1165a、沙美特罗和瑞米特罗进行了测试。结果证明，它们均为有效的支气管扩张剂，且与异丙肾上腺素或沙丁胺醇等效。
