Paterson I C, Willey R F, Shotter V, Grant I W, Crompton G K
Br J Dis Chest. 1975 Oct;69(0):267-72. doi: 10.1016/0007-0971(75)90095-9.
Double-blind studies of the bronchodilator effects of rimiterol, terbutaline and a combination of rimiterol and terbutaline were performed in patients with chronic asthma. An objective assessment in 21 patients showed no significant differences between the mean improvements in FEV1 during the first 30 minutes after drug administration. At 45 minutes and thereafter terbutaline produced a significantly greater degree of bronchodilatation than rimiterol or the combination of rimiterol and terbutaline. In a subjective study of 27 patients it was found that they were able to detect the more prolonged duration of bronchodilator activity of terbutaline but not the more rapid speed of onset of action of rimiterol.
对慢性哮喘患者进行了关于利米特罗、特布他林以及利米特罗与特布他林联合用药的支气管扩张作用的双盲研究。对21名患者的客观评估显示，给药后最初30分钟内，第一秒用力呼气量（FEV1）的平均改善情况之间无显著差异。在45分钟及之后，特布他林产生的支气管扩张程度明显大于利米特罗或利米特罗与特布他林的联合用药。在对27名患者的主观研究中发现，他们能够察觉到特布他林的支气管扩张作用持续时间更长，但察觉不到利米特罗起效更快。
