利福平与吖啶橙对大肠杆菌中F附加体的消除作用之间的关系
Relationships between curing of the F episome by rifampin and by acridine orange in Escherichia coli.
作者信息
Riva S, Fietta A, Berti M, Silvestri L G, Romero E
出版信息
Antimicrob Agents Chemother. 1973 Apr;3(4):456-62. doi: 10.1128/AAC.3.4.456.
Abstract
Subinhibitory doses of rifampin cured F(+)Escherichia coli cells from the episome. The target of the drug was transcription because E. coli mutants with a ribonucleic acid polymerase resistant to rifampin were not cured. The experimental conditions required for optimal curing with rifampin very closely resembled those required for curing with acridine orange. Mutants were found which are more resistant to curing by both acridine orange and rifampin. Probably the two drugs affect a common metabolic step, or alternatively they may inhibit the synthesis of a factor which is necessary for the replication of the episome.
摘要
亚抑制剂量的利福平可使游离基因从F(+)大肠杆菌细胞中消除。该药物的作用靶点是转录，因为对利福平具有抗性的核糖核酸聚合酶的大肠杆菌突变体并未被消除。用利福平进行最佳消除所需的实验条件与用吖啶橙进行消除所需的条件非常相似。发现了对吖啶橙和利福平的消除更具抗性的突变体。这两种药物可能影响一个共同的代谢步骤，或者它们可能抑制游离基因复制所必需的一种因子的合成。
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本文引用的文献
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THE EFFECT OF ACRIDINE DYES ON MATING TYPE FACTORS IN ESCHERICHIA COLI.吖啶染料对大肠杆菌交配型因子的影响
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Beginning a genetic analysis of conjugational transfer determined by the F factor in Escherichia coli by isolation and characterization of transfer-deficient mutants.通过分离和鉴定转移缺陷型突变体，对大肠杆菌中由F因子决定的接合转移进行遗传分析。
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