经皮吸收
Percutaneous absorption.
作者信息
Brisson P
出版信息
Can Med Assoc J. 1974 May 18;110(10):1182-5.
Abstract
Clinical effectiveness of topically applied medications depends on the ability of the active ingredient to leave its vehicle and penetrate into the epidermis. The stratum corneum is that layer of the epidermis which functionally is the most important in limiting percutaneous absorption, showing the characteristics of a composite semipermeable membrane. A mathematical expression of transepidermal diffusion may be derived from Fick's Law of mass transport; factors altering the rate of diffusion are discussed.
摘要
局部应用药物的临床疗效取决于活性成分离开其载体并渗透到表皮的能力。角质层是表皮中在限制经皮吸收方面功能上最重要的一层，表现出复合半透膜的特性。经表皮扩散的数学表达式可从菲克质量传输定律推导得出；文中讨论了改变扩散速率的因素。
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