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Antimicrob Agents Chemother. 1972 Apr;1(4):358-62. doi: 10.1128/AAC.1.4.358.
2
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Amoxicillin, a new penicillin antibiotic.阿莫西林，一种新型青霉素类抗生素。
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Bioequivalence evaluation of two capsule formulations of amoxicillin in healthy adult male bangladeshi volunteers: A single-dose, randomized, open-label, two-period crossover study.两种阿莫西林胶囊制剂在健康成年孟加拉国男性志愿者中的生物等效性评价：一项单剂量、随机、开放标签、两期交叉研究。
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本文引用的文献

1
Ampicillin activity in vitro and absorption and excretion in normal young men.氨苄西林在体外的活性以及在正常年轻男性体内的吸收与排泄。
Am J Med Sci. 1963 May;245:544-55.
2
New antistaphylococcal antibiotics. Comparative in vitro and in vivo activity of cephalothin, nafcillin, cloxacillin, oxacillin, and methicillin.新型抗葡萄球菌抗生素。头孢噻吩、萘夫西林、氯唑西林、苯唑西林和甲氧西林的体外及体内活性比较
Arch Intern Med. 1963 Jul;112:21-8. doi: 10.1001/archinte.1963.03860010067005.
3
-amino-p-hydroxybenzylpenicillin (BRL 2333), a new semisynthetic penicillin: absorption and excretion in man.α-氨基-对羟基苄青霉素（BRL 2333），一种新型半合成青霉素：人体中的吸收与排泄
Antimicrob Agents Chemother (Bethesda). 1970;10:427-30.
4
Single oral dose ampicillin-probenecid treatment of gnorrhea in the male.单次口服氨苄西林-丙磺舒治疗男性淋病。
JAMA. 1971 Mar 1;215(9):1449-53.
5
-amino-p-hydroxybenzylpenicillin (BRL 2333), a new broad-spectrum semisynthetic penicillin: in vivo evaluation.α-氨基-对羟基苄青霉素（BRL 2333），一种新型广谱半合成青霉素：体内评价
Antimicrob Agents Chemother (Bethesda). 1970;10:416-22.
6
-amino-p-hydroxybenzylpenicillin (BRL 2333), a new semisynthetic penicillin: in vitro evaluation.α-氨基对羟基苄青霉素（BRL 2333），一种新型半合成青霉素：体外评估
Antimicrob Agents Chemother (Bethesda). 1970;10:411-5. doi: 10.1128/AAC.10.3.411.
7
In vitro antimicrobial activity of 6(D(-) -amino-p-hydroxyphenylacetamido) penicillanic acid, a new semisynthetic penicillin.新型半合成青霉素6（D（-）-氨基-对羟基苯乙酰胺基）青霉烷酸的体外抗菌活性
Antimicrob Agents Chemother (Bethesda). 1970;10:407-10.
8
Pharmacological studies of 6 (D(-) -amino-p-hydroxyphenylacetamido) penicillanic acid in humans.6-（D（-）-氨基-对羟基苯乙酰氨基）青霉烷酸在人体中的药理学研究。
Antimicrob Agents Chemother (Bethesda). 1970;10:423-6.
9
Semiautomatic microtechnique for serial dilution-antibiotic sensitivity testing in the clinical laboratory.临床实验室中用于系列稀释-抗生素敏感性测试的半自动微量技术。
J Lab Clin Med. 1968 Oct;72(4):685-7.

阿莫西林：体外研究与药理学研究

Amoxicillin: in vitro and pharmacological studies.

作者信息

Bodey G P, Nance J

出版信息

Antimicrob Agents Chemother. 1972 Apr;1(4):358-62. doi: 10.1128/AAC.1.4.358.

DOI:10.1128/AAC.1.4.358
PMID:4598841
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC444222/
Abstract

Amoxicillin is a new semisynthetic penicillin which is active in vitro against gram-positive cocci (except penicillin G-resistant Staphylococcus aureus) and most isolates of Proteus mirabilis and Escherichia coli. Its in vitro activity is quite similar to ampicillin, but it produces higher serum levels after oral administration. The mean peak serum levels of amoxicillin in 11 normal volunteers were 2.30 mug/ml after 125 mg, 3.43 mug/ml after 250 mg, 6.75 mug/ml after 500 mg, and 9.90 mug/ml after 1 g. About 70% of the drug was excreted in the urine during the first 6 hr.

摘要

阿莫西林是一种新型半合成青霉素，体外对革兰氏阳性球菌（除耐青霉素G的金黄色葡萄球菌外）以及大多数奇异变形杆菌和大肠杆菌分离株具有活性。其体外活性与氨苄西林非常相似，但口服给药后血清水平更高。11名正常志愿者口服125mg阿莫西林后血清平均峰值水平为2.30μg/ml，250mg后为3.43μg/ml，500mg后为6.75μg/ml，1g后为9.90μg/ml。给药后的前6小时约70%的药物经尿液排泄。