阿莫西林：体外研究与药理学研究
Amoxicillin: in vitro and pharmacological studies.
作者信息
Bodey G P, Nance J
出版信息
Antimicrob Agents Chemother. 1972 Apr;1(4):358-62. doi: 10.1128/AAC.1.4.358.
Abstract
Amoxicillin is a new semisynthetic penicillin which is active in vitro against gram-positive cocci (except penicillin G-resistant Staphylococcus aureus) and most isolates of Proteus mirabilis and Escherichia coli. Its in vitro activity is quite similar to ampicillin, but it produces higher serum levels after oral administration. The mean peak serum levels of amoxicillin in 11 normal volunteers were 2.30 mug/ml after 125 mg, 3.43 mug/ml after 250 mg, 6.75 mug/ml after 500 mg, and 9.90 mug/ml after 1 g. About 70% of the drug was excreted in the urine during the first 6 hr.
摘要
阿莫西林是一种新型半合成青霉素，体外对革兰氏阳性球菌（除耐青霉素G的金黄色葡萄球菌外）以及大多数奇异变形杆菌和大肠杆菌分离株具有活性。其体外活性与氨苄西林非常相似，但口服给药后血清水平更高。11名正常志愿者口服125mg阿莫西林后血清平均峰值水平为2.30μg/ml，250mg后为3.43μg/ml，500mg后为6.75μg/ml，1g后为9.90μg/ml。给药后的前6小时约70%的药物经尿液排泄。
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2
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Arch Intern Med. 1963 Jul;112:21-8. doi: 10.1001/archinte.1963.03860010067005.
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