美洛西林：一种新型广谱青霉素的体外研究
Mezlocillin: in vitro studies of a new broad-spectrum penicillin.
作者信息
Bodey G P, Pan T
出版信息
Antimicrob Agents Chemother. 1977 Jan;11(1):74-9. doi: 10.1128/AAC.11.1.74.
Abstract
Mezlocillin is a new semisynthetic penicillin that inhibited 71% of the isolates of Serratia marcescens, 67% of Escherichia coli, 50% of Enterobacter spp., and 49% of Klebsiella spp. at a concentration of 12.5 mug/ml. It is also active against both indole-positive and -negative Proteus spp. and gram-positive cocci, except penicillin G-resistant Staphylococcus aureus. At a concentration of 100 mug/ml, it inhibited 94% of the isolates of Pseudomonas aeruginosa. It is more active than ampicillin, carbenicillin, and cephalothin against some gram-negative bacilli.
摘要
美洛西林是一种新型半合成青霉素，在浓度为12.5μg/ml时，它能抑制71%的粘质沙雷氏菌分离株、67%的大肠杆菌、50%的肠杆菌属细菌以及49%的克雷伯氏菌属细菌。它对吲哚阳性和阴性变形杆菌属细菌以及革兰氏阳性球菌也有活性，但对青霉素G耐药的金黄色葡萄球菌除外。在浓度为100μg/ml时，它能抑制94%的铜绿假单胞菌分离株。在对抗某些革兰氏阴性杆菌方面，它比氨苄西林、羧苄西林和头孢噻吩更具活性。
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