核黄疸是由胆红素抑制脑内磷酸己糖旁路活性所致吗？
Is kernicterus due to inhibition of brain hexose-monophosphate shunt activity by bilirubin?
作者信息
Thong Y H
出版信息
Med Hypotheses. 1979 Feb;5(2):297-302. doi: 10.1016/0306-9877(79)90131-2.
PMID:459982
Abstract
Degradation of biogenic amines in the central nervous system is accomplished by the monoamine oxidase system. The by-products of this reaction, hydrogen peroxide and amino aldehydes, are toxic to neurones. Detoxification of these by-products is normally mediated by generation of NADPH via the hexosemonophosphate (HMP) shunt. It is proposed that inhibition of the HMP shunt by unconjugated bilirubin leads to the toxic accumulation of hydrogen peroxide and aldehydes.
摘要
中枢神经系统中生物胺的降解是由单胺氧化酶系统完成的。该反应的副产物过氧化氢和氨基醛对神经元有毒性。这些副产物的解毒通常是通过磷酸己糖（HMP）支路生成NADPH来介导的。有人提出，未结合胆红素对HMP支路的抑制会导致过氧化氢和醛的毒性积累。
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