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Bilirubin inhibits hexose-monophosphate shunt activity of phagocytosing neutrophils.

作者信息

Thong Y H, Rencis V

出版信息

Acta Paediatr Scand. 1977 Nov;66(6):757-9. doi: 10.1111/j.1651-2227.1977.tb07985.x.

DOI:10.1111/j.1651-2227.1977.tb07985.x
PMID:920169
Abstract

Neutrophil hexose monophosphate (H.M.P.) shunt activity was measured by the conversion of 14C-1-glucose to 14CO2 during ingestion of polystyrene latex particles. Unconjugated bilrubin at the concentration of 1 X 10(5) M was found to markedly inhibit H.M.P. shunt activity. Since H.M.P. shunt activity of neutrophils is an important prerequisite of microbicidal function, it is suggested that jaundiced newborns may be more susceptible to bacterial infections.

摘要

相似文献

1
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