大肠杆菌连续培养中mutH1突变基因引起的诱变作用。
Mutagenesis by mutator gene mutH1 in continuous cultures of Escherichia coli.
作者信息
Nestmann E R, Hill R F
出版信息
J Bacteriol. 1974 Jul;119(1):33-5. doi: 10.1128/jb.119.1.33-35.1974.
Abstract
Mutability as a function of growth rate was examined in bacterial strains containing mutator gene mutH1. The rate of mutation to bacteriophage T5 resistance was found to be proportional to rate of growth in glucose-limited chemostat cultures. This finding supports the hypothesis that the mutator mutH1 gene product increases the error frequency during deoxyribonucleic acid replication.
摘要
在含有突变基因mutH1的细菌菌株中，研究了作为生长速率函数的可突变性。发现对噬菌体T5抗性的突变率与葡萄糖限制恒化器培养物中的生长速率成正比。这一发现支持了以下假设：突变基因mutH1的产物在脱氧核糖核酸复制过程中增加了错误频率。
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