KUBITSCHEK H E
Science. 1960 Mar 11;131(3402):730. doi: 10.1126/science.131.3402.730.
Accumulation of mutants in glucose-limited chemostats is proportional to growth rate, while in tryptophan-limited chemostats it is independent of growth rate. This behavior, which implies the failure of the error hypothesis, may be explainable on the basis of a unitary hypothesis: the results with glucose may be due to reversion or loss of latent mutants.
在葡萄糖受限的恒化器中,突变体的积累与生长速率成正比,而在色氨酸受限的恒化器中,它与生长速率无关。这种行为意味着错误假设不成立,可能基于单一假设来解释:葡萄糖实验结果可能是由于潜在突变体的回复突变或丢失。