疱疹净治疗带状疱疹：间歇性局部治疗的进一步评估
Idoxuridine in herpes zoster: further evaluation of intermittent topical therapy.
作者信息
Dawber R
出版信息
Br Med J. 1974 Jun 8;2(5918):526-7. doi: 10.1136/bmj.2.5918.526.
Abstract
In a randomized double-blind controlled trial of the value of intermittent topical idoxuridine in treating herpes zoster in 118 patients idoxuridine 5% in 100% dimethyl sulphoxide (DMSO), applied four-hourly for four days, significantly shortened the vesicular phase, healing time, and duration of pain; idoxuridine 25% applied two-hourly produced no greater benefit. The only side effects were transient tender erythema in three patients and "urticarial" oedema in two patients with dermographia.
摘要
在一项针对118例带状疱疹患者进行的间歇性局部应用碘苷价值的随机双盲对照试验中，100%二甲基亚砜（DMSO）中5%的碘苷，每4小时应用4天，显著缩短了水疱期、愈合时间和疼痛持续时间；每2小时应用25%的碘苷并未产生更大益处。仅3例患者出现短暂性压痛性红斑，2例皮肤划痕症患者出现“荨麻疹样”水肿这两种副作用。
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本文引用的文献
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SPREAD OF ZOSTER VIRUS IN HUMAN EMBRYONIC LUNG CELLS AND THE INHIBITORY EFFECT OF LODODEOXYURIDINE.带状疱疹病毒在人胚肺细胞中的传播及碘脱氧尿苷的抑制作用
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Treatment of zoster with idoxuridine in dimethyl sulphoxide. Results of two double-blind controlled trials.用二甲亚砜中的碘苷治疗带状疱疹。两项双盲对照试验的结果。
Br Med J. 1970 Dec 26;4(5738):776-80. doi: 10.1136/bmj.4.5738.776.
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Herpes encephalitis treated with intravenous idoxuridine.静脉注射碘苷治疗疱疹性脑炎。
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