骨髓瘤病中的肾脏与血管内凝血
The kidney and intravascular coagulation in myelomatosis.
作者信息
Ward A M, Preston F E
出版信息
Br Med J. 1974 Jun 8;2(5918):529-31. doi: 10.1136/bmj.2.5918.529.
In 15 out of 35 patients with myelomatosis histological examination showed intravascular fibrin within the glomeruli, and this was associated with proliferation of the mesangial complex in 12. The presence of intravascular fibrin and mesangial proliferation was not associated with any specific immunoglobulin abnormality or with the presence or absence of Bence Jones proteinuria. In addition to fibrin being present within glomerular capillaries it was also shown in intertubular capillaries in three cases of myelomatosis with acute tubular necrosis. It is suggested that intraglomerular coagulation and fibrin deposition may contribute to the genesis of renal failure in myelomatosis.
在35例骨髓瘤病患者中，15例的组织学检查显示肾小球内有血管内纤维蛋白，其中12例伴有系膜复合物增生。血管内纤维蛋白和系膜增生的存在与任何特定的免疫球蛋白异常或本周氏蛋白尿的有无均无关。除了肾小球毛细血管内存在纤维蛋白外，在3例伴有急性肾小管坏死的骨髓瘤病患者的肾小管间毛细血管中也发现了纤维蛋白。提示肾小球内凝血和纤维蛋白沉积可能在骨髓瘤病肾衰竭的发生中起作用。
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