Catovsky D, Ikoku N B, Pitney W R, Galton D A
Br Med J. 1970 Aug 22;3(5720):438-9. doi: 10.1136/bmj.3.5720.438.
Fourteen cases of myelomatosis associated with major thromboembolic complications are reported. Six patients died of pulmonary embolism, seven had deep-vein thrombosis as a presenting symptom, and three had evidence of amyloidosis. A preliminary estimate of the incidence of thromboembolism based on 376 patients admitted so far to the Medical Research Council's myelomatosis trial is about 3%, while pulmonary embolism accounted for about 3% of all deaths. Possibly a hypercoagulable state and the presence of amyloidosis may be important in the pathogenesis of this complication.
报告了14例伴有严重血栓栓塞并发症的骨髓瘤病。6例患者死于肺栓塞，7例以深静脉血栓形成作为首发症状，3例有淀粉样变性的证据。根据目前已纳入医学研究委员会骨髓瘤病试验的376例患者初步估算，血栓栓塞的发生率约为3%，而肺栓塞占所有死亡病例的约3%。高凝状态和淀粉样变性的存在可能在这一并发症的发病机制中起重要作用。
