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聚(寡)-L-赖氨酸核苷酸衍生物的合成与性质

[Synthesis and properties of nucleotide derivatives of poly(oligo)-L-lysine].

作者信息

Veĭko N N, Gromova E S, Shabarova Z A

出版信息

Mol Biol (Mosk). 1979 May-Jun;13(3):595-600.

PMID:460205
Abstract

Nucleotide derivatives (epsilon-amino groups of lysine residues) of lysine residues) of poly(oligo)-L-lysine were synthesized. The structure of the resulting compounds in solution were studied by circular dichroism techniques. Week stacking interactions of the nucleotide bases on the polypeptide template were found to be characteristic of these compounds. It has been shown that the nucleotide derivatives of poly(oligo)-L-lysine are not involved in complementary interactions with the polynucleotides.

摘要

合成了聚(寡)-L-赖氨酸赖氨酸残基的核苷酸衍生物(赖氨酸残基的ε-氨基)。通过圆二色性技术研究了所得化合物在溶液中的结构。发现这些化合物的特征是多肽模板上核苷酸碱基的弱堆积相互作用。已经表明,聚(寡)-L-赖氨酸的核苷酸衍生物不参与与多核苷酸的互补相互作用。

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