A critical search for evidence of changes in levels of circulating IgE in patients with cancer.

Serum-IgE levels in 95 patients with various advanced malignant conditions were determined by the radioimmunosorbent test. The results obtained did not support the claims of other workers that a high proportion of untreated cancer patients have extremely high circulating IgE levels, attributable to the release of a tumour constituent which interferes with this radioimmunoassay procedure.